Practical and Efficient Method for α-Sialylation with an Azide Sialyl Donor Using a Microreactor |
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Authors: | Yosuke Uchinashi Katsunori Tanaka Yoshiyuki Manabe Yukari Fujimoto |
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Institution: | 1. Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan;2. RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan |
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Abstract: | Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. |
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Keywords: | α-Sialylation Sialic acid Micromixer Comet X-01 |
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