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Primary amine drug sensitive electrodes based on macrocyclic polyethers with 2,2′-dinaphthyl subunits
Authors:Kun-Yuan Liu  Zeng-Rong Zhang  Ru-Qin Yu
Affiliation:(1) Department of Chemistry and Chemical Engineering, Hunan University, Changsha, People's Republic of China
Abstract:Dinaphthyl macrocyclic polyethers were synthesized and used as neutral carriers for preparing primary amine drug sensitive PVC membrane electrodes. Contrary to the ion-associate based electrodes, which show an excellent potentiometric response to quaternary ammonium ions and the like, but a very poor response to primary amines, the macrocyclic polyether-based electrodes showed potentiometric response characteristics with primary amines preferred. Dinaphthyl macrocyclic polyether-based electrodes are superior to those based on common macrocyclic polyethers for their potentiometric selectivity coefficients much lower than those of the latter. The main characteristics of a dinaphthyl-20-crown-6-based benzyl amine sensitive electrode are as follows: linear response range, 4.2 × 10–5 – 1.0 ×10–1M; slope, 51.3 mV/decade; and detection limit, 4.6 × 10–6M. A mexiletine sensitive electrode was prepared using dinaphthyl-23-crown-7 with following performance features: linear response range, 2.0 × 10–5 – 1.0 ×10–1M; slope, 52.1mV/decade; and detection limit, 5.0 × 10–6M.
Keywords:primary amine drug  ion-selective electrode  macrocyclic polyether  dinaphthol
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