Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support |
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| Authors: | Mortezaei Reza Ida Satoru Campbell David A |
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| Institution: | (1) Affymax Research Institute, 3410 Central Expressway, Santa Clara, CA, 95051, U.S.A;(2) Bayer Pharmaceuticals, 400 Morgan Lane, West Haven, CT, 06516-4175, U.S.A |
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| Abstract: | A general method was developed to generate six-membered cyclic thiazinanes on solid support. Three diversity sites were introduced into this scaffold using primary amines, aldehydes, and 2-bromoalkanoic acids. The methodology to prepare individual cyclic thiazinanes as well as combinatorial libraries of these compounds is described. |
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| Keywords: | combinatorial library LC/MS scaffold solid support synthesis 1 4-thiazinanes |
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