| 聚己内酯聚醚嵌段共聚物和共混物的表面性质对其药物释放行为的影响 |
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| 引用本文： | 王卫华,贝建中,王智峰,王身国.聚己内酯聚醚嵌段共聚物和共混物的表面性质对其药物释放行为的影响[J].高分子学报,1995,0(2):253-256. |
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| 作者姓名： | 王卫华 贝建中 王智峰 王身国 |
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| 作者单位： | 中国科学院化学研究所 |
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| 摘 要： | 聚己内酯聚醚嵌段共聚物和共混物的表面性质对其药物释放行为的影响王卫华，贝建中，王智峰，王身国（中国科学院化学研究所北京１０００８０）关键词聚己内酯聚醚嵌段共聚物，共混物，电子能谱，表面性质，药物释放行为聚己内醋（ＰＣＬ）具有优良的药物通透性和生物相容...
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| 关 键 词： | 聚己内酯聚醚嵌段共聚物，共混物，电子能谱，表面性质，药物释放行为 |
| 收稿时间： | 1994-06-12 |
EFFECT OF SURFACE PROPERTIES OF POLYCAPROLACTONE-POLYTHER COPOLYMER AND BLENDED POLYMER ON THEIR DRUG RELEASE BEHAVIOR |
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| WANG Wei-hua,BEI Jian-zhong,WANG Zhi-feng,WANG Shen-guo.EFFECT OF SURFACE PROPERTIES OF POLYCAPROLACTONE-POLYTHER COPOLYMER AND BLENDED POLYMER ON THEIR DRUG RELEASE BEHAVIOR[J].Acta Polymerica Sinica,1995,0(2):253-256. |
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| Authors: | WANG Wei-hua BEI Jian-zhong WANG Zhi-feng WANG Shen-guo |
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| Institution: | Institute of Chemistry; Academy of Sinica; Beijing 100080 |
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| Abstract: | he surface properties of polycaprolactone (PCL)-poly (ethyleneglycol) (PEG) block copolymer(PCE) and blend(B-PCE) of PCL and PEG obviouslyeffect on drug release behavior of the polymer. In this paper, both-surface propertiesof PCE and B--PCE are studied and compared by measuring their water sorption.contact angle and XPS technique. The effect of polyether segment content in PCEand B-PCE on the hydrophilicity is discussed. The results show that hydrophilicpolyether segment moves towards the surface and enriches on the surface for eitherPCE or B-PCE. The enrichment content of polyether segment of PCE and the hydrophilicity of its surface are higher than that of B-PCE. The reason of different drugrelease rate for the PCE and B-PCE has been suggested. |
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| Keywords: | Polycaprolactone-poly(ethylene glycol) block copolymer Blended copolymer XPS spectrometer Surface properties Drug release behavior |
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