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| Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt（Ⅱ） Complexes | |
| 引用本文： | 胡伟 李建章 王莹 李慈 杜娟 孟祥光 胡常伟 曾宪诚. Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt（Ⅱ） Complexes[J]. 中国化学, 2006, 24(11): 1498-1504. DOI: 10.1002/cjoc.200690283 |
| 作者姓名： | 胡伟 李建章 王莹 李慈 杜娟 孟祥光 胡常伟 曾宪诚 |
| 作者单位： | [1]Department of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China [2]Department of Chemistry, Sichuan University of Science ＆ Engineering, Zigong, Sichuan 643000, China [3]College of Bioengineering, Chongqing Technology and Business University, Chongqing 400060, China |
| 基金项目： | Project supported by the Educational Department of Sichuan Government （No.2005D007） and the National Natural Science Foundation of China （Nos.20173038, 20107004）. |
| 摘 要： | Two cobalt（Ⅱ） complexes of the Schiff base with morpholino or aza-crown ether pendants, CoL^1 and CoL^2, as mimic hydrolytic metalloenzyme, were used in catalytic hydrolysis of carboxylic ester （PNPP）. The analysis of specific absorption spectra of the hydrolytic reaction systems indicates that key intermediates, made up of PNPP and Co（Ⅱ） complexes, have been formed in reaction processes of the PNPP catalytic hydrolysis. The mechanism of PNPP catalytic hydrolysis has been proposed based on the analytic result of specific absorption spectrum. A kinetic mathematical model, applied to the calculation of the kinetic parameter of PNPP catalytic hydrolysis, has been established based on the mechanism proposed. The acid effect of buffer solution, structural effect of the complexes, and effect of temperature on the rate of PNPP hydrolysis catalyzed by the complexes have been also discussed. |
| 关 键 词： | 席夫碱钴（Ⅱ）配合物 模拟水解酶 催化动力学 羧酸脂 |
| 收稿时间： | 2006-04-10 |
| 修稿时间： | 2006-04-102006-06-08 |
Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt(II) Complexes |
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| HU, Wei, LI, Jian-Zhang, WANG, Ying, LI, Ci, DU, Juan, MENG, Xiang-Guang, HU, Chang-Wei, ZENG, Xian-Cheng. Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt(II) Complexes[J]. Chinese Journal of Chemistry, 2006, 24(11): 1498-1504. DOI: 10.1002/cjoc.200690283 | |
| Authors: | HU Wei LI Jian-Zhang WANG Ying LI Ci DU Juan MENG Xiang-Guang HU Chang-Wei ZENG Xian-Cheng |
| Abstract: | Two cobalt(II) complexes of the Schiff base with morpholino or aza‐crown ether pendants, CoL1 and CoL2, as mimic hydrolytic metalloenzyme, were used in catalytic hydrolysis of carboxylic ester (PNPP). The analysis of specific absorption spectra of the hydrolytic reaction systems indicates that key intermediates, made up of PNPP and Co(II) complexes, have been formed in reaction processes of the PNPP catalytic hydrolysis. The mechanism of PNPP catalytic hydrolysis has been proposed based on the analytic result of specific absorption spectrum. A kinetic mathematical model, applied to the calculation of the kinetic parameter of PNPP catalytic hydrolysis, has been established based on the mechanism proposed. The acid effect of buffer solution, structural effect of the complexes, and effect of temperature on the rate of PNPP hydrolysis catalyzed by the complexes have been also discussed. |
| Keywords: | Schiff base cobalt(II) complex mimic hydrolase catalytic kinetics carboxylic ester |
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