Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples |
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Authors: | A. Zurutuza P.A.G. Cormack L. Dambies R. Bischoff |
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Affiliation: | a Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, UK b University of Groningen, Center of Pharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands |
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Abstract: | Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (μg/ml). Under optimised MISPE conditions, recoveries of analyte were high (>70%) and excellent discrimination between imprinted and non-imprinted materials observed. |
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Keywords: | Molecularly imprinted polymers Solid-phase extraction Cocaine Cocaine metabolites Benzoylecgonine |
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