| 控制细胞生死的一把新钥匙TRAIL |
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| 引用本文： | 易巍,齐义鹏.控制细胞生死的一把新钥匙TRAIL[J].武汉大学学报(理学版),2000,46(4):511-514. |
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| 作者姓名： | 易巍 齐义鹏 |
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| 作者单位： | 武汉大学,病毒研究所,武汉,430072 |
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| 基金项目： | 国家自然科学高技术新探索基金!( 3 9880 0 3 1) |
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| 摘 要： | TRAIL是最近克隆的 TNF家族中的一个新成员 ,其最显著的特异性是 :能迅速诱导肿瘤细胞凋亡而对正常细胞无影响 .其受体和竞争受体的多样性表明 TRAIL具有与 TNF不同的控制细胞死亡的独特机制 ,TRAIL通过与不同的细胞表面特异性受体结合来调控死亡信号的转导过程 .研究表明 ,TRAIL对肿瘤的杀伤效率高 ,特异性强 ,是一个很有潜力的抗肿瘤细胞因子 .
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| 关 键 词： | TRAIL 细胞凋亡 TNF家族 肿瘤治疗 受体死亡域 |
| 修稿时间： | 1999-10-15 |
A New Member of TNF Family-TRAIL |
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| YI Wei,QI Yi-peng.A New Member of TNF Family-TRAIL[J].JOurnal of Wuhan University:Natural Science Edition,2000,46(4):511-514. |
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| Authors: | YI Wei QI Yi-peng |
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| Abstract: | TRAIL is a new member of TNF family, which is cloned recently. Its distinguished specificity is that it can induce the apoptosis of tumor cells having no effect with normal cells. The diversity of receptors and competition receptors shows TRAIL has the special mechanism different from TNF controlling the apoptosis of cells. TRAIL regulates the transduction of death signal by binding the different cell surface specialized receptors. The research showed TRAIL is a potential anti\|tumor cell factor which has high efficiency and specificity in killing tumor cells. |
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| Keywords: | TRAIL apoptosis TNF family tumor therapy receptor domain |
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