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A novel and efficient one-pot synthesis of furo[3′,4′:5,6]pyrido[2,3-c]pyrazole derivatives using organocatalysts |
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| Authors: | Chun-Ling Shi Sung Hong Kim Shun-Jun Ji |
| Institution: | a College of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu 210096, PR China b College of Chemistry and Chemical Engineering, Key Laboratory of Organic Synthesis of Jiangsu Province, Suzhou University, Suzhou 215123, PR China c Analysis Research Division, Daegu Center, Korea Basic Science Institute, Daegu 702-701, South Korea |
| Abstract: | A novel approach to one-pot synthesis of dihydrofuro3′,4′:5,6]pyrido2,3-c]pyrazole and indeno2′,1′:5,6]pyrido2,3-c]pyrazole derivatives have been investigated using organocatalysts that are recyclable. This new protocol has the advantages of environmental friendliness, higher yield, low cost, as well as convenient operation. The catalytic efficiency of various small organocatalysts such as l-proline, trans-4-hydroxy-l-proline, l-thiaproline, cinchonidine, (+)-cinchonine, and dl-2-phenylglycine has also been studied. |
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