| 乳酸-磷酸酯共聚物为载体的高分子药物的合成及其控释研究 |
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| 引用本文： | 范昌烈,李兵,刘振华,卓仁禧.乳酸-磷酸酯共聚物为载体的高分子药物的合成及其控释研究[J].高等学校化学学报,1996,17(11):1788. |
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| 作者姓名： | 范昌烈 李兵 刘振华 卓仁禧 |
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| 作者单位： | 武汉大学化学系, 武汉, 430072 |
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| 摘 要： | 以5-氟尿嘧啶(5-FU)为药物模型,以乳酸-磷酸酯共聚物为高分子药物载体,合成了侧链带药的乳酸-磷酸酯共聚物药物。用1HNMR、IR、UV谱对其结构进行了表征。测定高分子药物中5-FU的含量,研究了高分子药物的体外释药性能及共聚物组成对释药性能的影响。
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| 关 键 词： | 药物控制释放 高分子药物 乳酸-磷酸酯共聚物 |
| 收稿时间： | 1995-10-30 |
Studies on Synthesis and Controlled-release of Polymer Drug Using Lactic Acid-Phosphate Copolymer as Drug Carriers |
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| FAN Chang-Lie,LI Bing,LIU Zhen-Hua,ZHUO Ren-Xi.Studies on Synthesis and Controlled-release of Polymer Drug Using Lactic Acid-Phosphate Copolymer as Drug Carriers[J].Chemical Research In Chinese Universities,1996,17(11):1788. |
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| Authors: | FAN Chang-Lie LI Bing LIU Zhen-Hua ZHUO Ren-Xi |
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| Institution: | Department of Chemistry, Wuhan University, Wuhan, 430072 |
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| Abstract: | A kind of polymer drug,using 5-flurouril as model drug,lactic acid-phosphate copolymers as polymer drug carriers,was synthesized.The copolymers were characterized by 1H NMR,IR and UV spectroscopy.The contents of 5-fluorouril were determined by UV spectroscopy.The drug release in vitro of the copolymers was studied and the influence of the copolymer composition on the drug release in vitro was investigated. |
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| Keywords: | Drug controlled-release Polymer drug Lactic acid-phosphate copolymer |
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