In vivo monitoring of skeletal aluminum burden in patients with renal failure |
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Authors: | K J Ellis S Kelleher A Raciti J Savory M Wills |
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Institution: | (1) Medical Department, Brookhaven National Laboratory, 11973 Upton, New York, (USA);(2) Health Science Center, SUNY-Stony Brook, 11794 Stony Brook, New York, (USA);(3) University of Virginia Medical School, 22908 Charlottesville, Virginia, (USA) |
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Abstract: | In vivo neutron activation analysis was used to examine the total body and partial body (hand) aluminum levels in patients with end-stage renal failure. Patients maintained on chronic hemodialysis had higher mean body burdens of aluminum than, did those clinically managed without dialysis. Approximately 70% of the patients examined indicated elevated levels of body or skeletal aluminum. A significant correlation was observed between the in vivo aluminum/calcium ratio obtained for the hand measurement and the increase in serum aluminum levels following a disferroxamine infusion test. The direct in vivo monitoring of hand Al/Ca values in patients may provide an alternate choice to bone biopsy for the detection of aluminum intoxication. |
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