Synthesis and molecular docking of some new 3,5-bis-(diazipine,pyrazolopyrimidine, pyrimidine,and pyrazole) pyridine derivatives and their in vitro and in vivo biological evaluation as potential antitumor agents |
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| Authors: | Nanees N. Soliman Yasmin M. Tag Nesma M. Bayoumy |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt;2. Department Oral Biology, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Mansoura, Egypt;3. Department Dental Biomaterials, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Mansoura, Egypt |
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| Abstract: | Bis enaminone derivative 6 was reactive enaminone to synthesize new heterocyclic compounds containing diazipine, pyrazolopyrimidine, triazolopyrimidine, and pyrazole moieties by reaction with different bifunctional reagents. Structures of new compounds were confirmed by analytical and spectral data. Moreover, the new compounds were screened in-vitro as antitumor agents for Ehrlich ascites at different concentration. The results showed the compounds 18 , 19, and 20a have a good activity. In addition to, the molecular docking of these mentioned compounds was studied using vascular endothelial growth factor receptor. |
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