Nitration of 2-substituted pyrimidine-4,6-diones,structure and reactivity of 5,5-gem-dinitropyrimidine-4,6-diones |
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| Authors: | Langlet Abraham Latypov Nikolaj V Wellmar Ulf Bemm Ulf Goede Patrick Bergman Jan Romero Ivan |
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| Affiliation: | Department of Organic Chemistry, CNT, NOVUM Research Park, SE-141 57 Huddinge, Sweden. |
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| Abstract: | Nitration of some 2-substituted pyrimidine-4,6-diones in sulfuric acid was studied, which afforded previously unknown 5,5-gem-dinitropyrimidine-4,6-diones in high yields. The gem-dinitro products were easily attacked by nucleophiles with concomitant formation of gem-dinitroacetyl derivatives, which in turn could be further hydrolyzed to salts of dinitromethane and triureas. |
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