Photodynamic therapy with aluminum-chloro-phtalocyanine induces necrosis and vascular damage in mice tongue tumors |
| |
| Authors: | João Paulo Figueiró Longo Silene Paulino Lozzi Andreza Ribeiro Simioni Paulo César Morais Antônio Cláudio Tedesco Ricardo Bentes Azevedo |
| |
| Institution: | 1. Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília DF 70910-900, Brazil;2. Department of Chemistry, University of São Paulo – USP, Ribeirão Preto, Brazil;3. Institute of Physics – Applied Physics, University of Brasília, Brasília DF 70910-900, Brazil |
| |
| Abstract: | In this paper we describe the efficacy of the liposomal-AlClPc (aluminum-chloro-phthalocyanine) formulation in PDT study against Ehrlich tumor cells proliferation in immunocompetent swiss mice tongue. Experiments were conduced in sixteen tumor induced mice that were divided in three control groups: (1) tumor without treatment; (2) tumor with 100 J/cm2 laser (670 nm) irradiation; and (3) tumor with AlClPc peritumoral injection; and a PDT experimental group when tumors received AlClPc injection followed by tumor irradiation. Control groups present similar macroscopically and histological patterns after treatments, while PDT treatment induced 90% of Ehrlich tumor necrosis after 24 h of one single application, showing the efficacy of liposome-AlClPc (aluminum-chloro-phthalocyanine) mediated PDT on the treatment of oral cancer. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
