2D NMR Trace Analysis by Continuous Hyperpolarization at High Magnetic Field |
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Authors: | Nan Eshuis Ing Ruud L E G Aspers Bram J A van?Weerdenburg Dr Martin C Feiters Prof?Dr Floris P J T Rutjes Prof?Dr Sybren S Wijmenga Dr Marco Tessari |
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Institution: | Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands) |
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Abstract: | Nuclear magnetic resonance is often the technique of choice in chemical analysis because of its sensitivity to molecular structure, quantitative character, and straightforward sample preparation. However, determination of trace analytes in complex mixtures is generally limited by low sensitivity and extensive signal overlap. Here, we present an approach for continuous hyperpolarization at high magnetic field that is based on signal amplification by reversible exchange (SABRE) and can be straightforwardly incorporated in multidimensional NMR experiments. This method was implemented in a 2D correlation experiment that allows detection and quantification of analytes at nanomolar concentration in complex solutions. |
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Keywords: | hyperpolarization multidimensional NMR spectroscopy para‐hydrogen signal amplification trace analysis |
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