Novel antitumor dinuclear platinum (II) complexes with a new chiral tetradentate ligand as the carrier group |
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| Authors: | Chuanzhu Gao Yan Zhang Tianshuai Wang Ji Chen Yunxu Qian Bo Yang Shaohua Gou Peng Dong Yingjie Zhang |
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| Institution: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China;2. Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, China;3. Engineering Laboratory for Advanced Battery and Material of Yunnan Province, Kunming, China;4. Jiangsu Province Hi‐Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, China |
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| Abstract: | Seven dinuclear platinum(II) complexes with a novel chiral tetradentate ligand, (1R,1′R,2R,2′R)‐N1,N1′‐(1,4‐phenylenebis(methylene))dicyclohexane‐1,2‐diamine, were designed, synthesized and spectrally characterized. All the complexes were evaluated for their in vitro cytotoxicity against human HepG‐2, A549, HCT‐116 and MCF‐7 cancer cell lines. The results indicated that all compounds showed positive biological activity against HepG‐2, A549 and HCT‐116 cancer cell lines. In particular, compounds D7 and D2 showed better activity than carboplatin against HepG‐2 and A549 and compound D7 also showed an activity close to that of oxaliplatin. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | 1R 2R‐diaminocyclohexane derivative intercalative binding dinuclear platinum(II) complexes antitumor activity |
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