Zinc‐Catalyzed Dehydrogenative Cross‐Coupling of Terminal Alkynes with Aldehydes: Access to Ynones |
| |
| Authors: | Shan Tang Li Zeng Yichang Liu Prof Aiwen Lei |
| |
| Institution: | 1. College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P.R. China) http://aiwenlei.whu.edu.cn/Main_Website/;2. National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022 (P.R. China) |
| |
| Abstract: | Because of the lack of redox ability, zinc has seldom been used as a catalyst in dehydrogenative cross‐coupling reactions. Herein, a novel zinc‐catalyzed dehydrogenative C(sp2)? H/C(sp)? H cross‐coupling of terminal alkynes with aldehydes was developed, and provides a simple way to access ynones from readily available materials under mild reaction conditions. Good reaction selectivity can be achieved with a 1:1 ratio of terminal alkyne and aldehyde. Various terminal alkynes and aldehydes are suitable in this transformation. |
| |
| Keywords: | C H activation cross‐coupling dehydrogenation homogeneous catalysis zinc |
|
|
