Synthesis,characterization and assessment of the cytotoxic activity of Cu(II), Fe(III) and Mn(III) complexes of camphoric acid‐derived salen ligands |
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| Authors: | Dina Murtinho Zênis N. da Rocha Ana Salomé Pires Roberto P. Jiménez Ana Margarida Abrantes Mafalda Laranjo Ana Catarina Mamede João Eduardo Casalta‐Lopes Maria Filomena Botelho Alberto A. C. C. Pais Sandra C. C. Nunes Hugh D. Burrows Telma Costa M. Elisa Silva Serra |
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| Affiliation: | 1. Centro de Química, Department of Chemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal;2. Instituto de Química, Universidade Federal da Bahia, Salvador, Bahia, Brazil;3. Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal;4. Biophysics Unit, Faculty of Medicine, University of Coimbra, Coimbra, Portugal;5. Centre of Investigation on Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal;6. CICS‐UBI, Health Sciences Research Centre, University of Beira Interior, Covilh?, Portugal |
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| Abstract: | Novel Cu(II), Fe(III) and Mn(III) salen‐type metal complexes from (1R,3S)‐N,N′‐bis[salicylidene]‐1,3‐diamino‐1,2,2‐trimethylcyclopentane were synthesized and screened for their in vitro cytotoxic activity against three human cancer cell lines: melanoma, colorectal and breast. In vitro experiments carried out with the three metal complexes show that the copper complex exhibits the highest cytotoxic activity towards all cell lines studied, presenting IC50 values of 3.32–6.71 μM. A significant improvement in the anti‐proliferative effect, by 20‐fold, is observed with this complex when compared with conventional chemotherapy. The relationship between structure, redox characteristics and biological activity in human cancer cell lines was evaluated for the most efficient Cu(II) complex and associated with theoretical calculations. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | cytotoxic activity metal complexes salen ligands electrochemical studies theoretical calculations |
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