Application of AM SURE™ resin to solid-phase peptide synthesis |
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| Authors: | Tae-Kyung Lee Sang-Myung Lee Jang-Woong Byun |
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| Institution: | a School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea
b BeadTech Inc., Institute for Chemical Processes, Seoul National University, Seoul 151-744, Republic of Korea |
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| Abstract: | A core-shell structure was found in AM SURE™ resin, in which most amino groups were located at the skin layer. The AM SURE™ resin revealed better synthetic efficiency, compared to the noncore-shell type resin in the synthesis of the fragment 65-74 of acyl carrier protein, the fragment 27-35 of HIV (human immunodeficiency virus) fusion inhibitor (T-20) and the Jung-Redemann 10-mer. |
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| Keywords: | Core-shell type Aminomethyl polystyrene resin Solid-phase peptide synthesis |
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