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Regioselective palladium-catalyzed phenylation of ethyl 4-oxazolecarboxylate |
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| Authors: | Christophe Hoarau Alexis Du Fou de Kerdaniel Pierre Grandclaudon Francis Marsais |
| Affiliation: | a Laboratoire de Chimie Organique Fine et Hétérocyclique, CNRS UMR 6014, IRCOF, Univerité et INSA de Rouen Place E. Blondel, BP 08, 76131 Mont-Saint-Aignan Cedex, France b Laboratoire de Chimie Organique Physique, CNRS UMR 8009 ‘COM’, UST Lille 1, 59655 Villeneuve d’Ascq Cedex, France |
| Abstract: | The efficient and regioselective palladium-catalyzed C-2 arylation of ethyl 4-oxazolecarboxylate 1 with phenyliodide is described. The different parameters (solvent, base, ligand and catalyst) for the optimal conditions of this arylation process have been screened. |
| Keywords: | Ethyl 4-oxazolecarboxylate Aryloxazoles Direct coupling Palladium |
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