An efficient approach to the synthesis of 3-vinylidene tetrahydropyrans via Prins-type cyclization |
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| Authors: | Magdalena Dziedzic Bart?omiej Furman |
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| Affiliation: | Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland |
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| Abstract: | ![]()
Lewis acid-catalyzed intramolecular reactions of oxocarbenium ions with propargylsilanes are described. The results obtained indicate that trimethylsilyl trifluoromethanesulfonate (TMSOTf) efficiently catalyses cyclization leading to the corresponding 3-vinylidene tetrahydropyrans in high yield as single isomers. |
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| Keywords: | Propargylsilanes Tetrahydropyrans Prins cyclization |
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