Sulfamic acid: an efficient, cost-effective and recyclable solid acid catalyst for the Friedlander quinoline synthesis |
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Authors: | JS Yadav P Purushothama Rao D Sreenu R Srinivasa Rao V Naveen Kumar K Nagaiah AR Prasad |
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Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India |
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Abstract: | o-Aminoaryl ketones undergo smooth condensation with α-methylene ketones in the presence of sulfamic acid (NH2SO3H) (SA) under mild reaction conditions to afford the corresponding polysubstituted quinolines in excellent yields. The catalyst can be recovered by simple filtration and can be recycled in subsequent reactions. The method is simple, cost-effective and environmentally benign. |
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Keywords: | Sulfamic acid (SA) o-Aminoaryl ketones α-Methylene ketones Quinolines |
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