A vicarious synthesis of unsymmetrical meta- and para- terphenyls from 2H-pyran-2-ones |
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Authors: | Atul Goel Deepti Verma Fateh Veer Singh |
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Institution: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India |
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Abstract: | An innovative synthesis of terphenyls functionalized with electron-withdrawing or -donating substituents is described and illustrated by carbanion-induced ring transformation of 2H-pyran-2-ones with 2-methoxyacetophenone in excellent yields. The existing protocols for the synthesis of terphenyls are generally inter- and intramolecular aryl-aryl cross couplings in the presence of metal complexes. In this letter, we report a potentially useful alternative to conventional metal-catalyzed cross-coupling reactions. |
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Keywords: | Terphenyl C-C Bond formation Lactone Pyran-2-one |
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