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A simple and clean procedure for the synthesis of polyhydroacridine and quinoline derivatives: reaction of Schiff base with 1,3-dicarbonyl compounds in aqueous medium |
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| Authors: | Xiang-Shan Wang Mei-Mei Zhang Da-Qing Shi Shu-Jiang Tu Xian-Yong Wei |
| Affiliation: | a Department of Chemistry, Xuzhou Normal University, Xuzhou Jiangsu 221116, China b School of Chemical Engineering, China University of Mining and Technology, Xuzhou Jiangsu 221008, China c The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116, China |
| Abstract: | A clean and simple synthesis of benzo[c]acridine, benzo[a]acridine, pyrido[2,3-c]acridine and benzo[f]quinoline derivatives was accomplished in good to excellent yields via the reaction of Schiff base with 1,3-dicarbonyl compounds in aqueous medium catalyzed by TEBA. The structures were characterized by 1H NMR, IR and elemental analysis, and confirmed by X-ray diffraction study. |
| Keywords: | Acridine Quinoline Schiff base Aqueous medium TEBA |
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