Synthesis of Fmoc-protected aza-β-amino acids via reductive amination of glyoxylic acid |
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| Authors: | Olivier Busnel |
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| Affiliation: | Groupe ‘Ciblage et Auto-Assemblages Fonctionnels’, UMR 6510 CNRS, Institut de Chimie, Université de Rennes I, 263 Av. du Général Leclerc, F-35042 Rennes Cedex, France |
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| Abstract: | The reductive amination of glyoxylic acid, with a protected Fmoc hydrazine, has been developed as a simple and efficient method for the preparation of Fmoc-aza-β3-amino acid residues (aza-β3-aa). Anchoring on resin of these residues will be described as well as the synthesis of hybrid peptide. |
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| Keywords: | Aza-β3-amino acid Fmoc protecting group Peptidomimetics Loading resin Reductive amination |
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