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New cleavable isocyanides for the combinatorial synthesis of α-amino acid analogue tetrazoles |
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| Authors: | Josef Mayer Michael Umkehrer Cédric Kalinski Günther Ross Christoph Burdack |
| Institution: | a Priaton GmbH, Bahnhofstr. 9-15, D-82327 Tutzing, Germany b Technical University Munich, Lichtenbergstr. 4, D-85747 Garching, Germany |
| Abstract: | 3-Substituted 3-isocyano propionates as new cleavable isocyanides in combinatorial tetrazole synthesis via Ugi-reaction are introduced. The obtained 5-substituted tetrazoles are transformed into carboxylic acid isosteric 5-substituted 1H-tetrazoles under basic cleavage conditions. |
| Keywords: | Cleavable isocyanides 1H-Tetrazole 1H-Tetrazole U-4CR Combinatorial chemistry |
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