A Review on Phytochemicals of the Genus Maytenus and Their Bioactive Studies |
| |
| Authors: | Yuan-Yuan Huang Lu Chen Guo-Xu Ma Xu-Dong Xu Xue-Gong Jia Fu-Sheng Deng Xue-Jian Li Jing-Quan Yuan |
| |
| Institution: | 1.Scientific Experimental Center of Guangxi University of Chinese Medicine, Nanning 530200, China; (Y.-Y.H.); (X.-G.J.); (F.-S.D.);2.School of Chemistry and Materials, Nanning Normal University, Nanning 530001, China;3.Research Department of Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China;4.Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China; (G.-X.M.); (X.-D.X.) |
| |
| Abstract: | The genus Maytenus is a member of the Celastraceae family, of which several species have long been used in traditional medicine. Between 1976 and 2021, nearly 270 new compounds have been isolated and elucidated from the genus Maytenus. Among these, maytansine and its homologues are extremely rare in nature. Owing to its unique skeleton and remarkable bioactivities, maytansine has attracted many synthetic endeavors in order to construct its core structure. In this paper, the current status of the past 45 years of research on Maytenus, with respect to its chemical and biological activities are discussed. The chemical research includes its structural classification into triterpenoids, sesquiterpenes and alkaloids, along with several chemical synthesis methods of maytansine or maytansine fragments. The biological activity research includes activities, such as anti-tumor, anti-bacterial and anti-inflammatory activities, as well as HIV inhibition, which can provide a theoretical basis for the better development and utilization of the Maytenus. |
| |
| Keywords: | Maytenus triterpenoids sesquiterpenes alkaloids synthesis of maytansine |
|
|
