首页 | 本学科首页   官方微博 | 高级检索  
     


Characterization of the differential protein expression associated with thermoresistance in human gastric carcinoma cell lines
Authors:Sinha P  Poland J  Schnölzer M  Celis J E  Lage H
Affiliation:Institut für Laboratoriumsmedizin und Pathobiochemie, Universit?tsklinikum Charité, Berlin, Germany. pranav.sinha@charite.de
Abstract:
Resistance to chemotherapeutic agents is one of the major problems faced during palliative therapy of tumor cells. Thus, chemotherapy is frequently combined with other modes of therapy such as radiation therapy and/or hyperthermia. Tumor cells respond to heat stress with development of thermotolerance and the interactions between chemo- and thermoresistance phenomena are not clearly understood. In this paper, we analyze the differential protein expression in vitro in human stomach cancer cells, their chemoresistant and thermoresistant counterparts using proteomics. The immediate aim was to identify sets of proteins that may lead to the development of thermoresistance. Based on these results, we aim to develop functional tests and methods for the modulation of thermoresistance and chemoresistance phenomena that may assist the therapy of inoperable cancers.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号