Recent developments on creation of artificial metalloenzymes |
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Authors: | Takashi Matsuo Teruyuki Miyake Shun Hirota |
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Affiliation: | Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan |
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Abstract: | Organic synthesis using biocatalysts has been developed over many years and is still a prominent area of research. In this context, various hybrid biocatalysts composed of a synthetic metal complex catalyst and a protein scaffold (i.e. “artificial metalloenzymes”) have been constructed. One of the most recent research areas in biocatalysts-mediated synthesis is C![/>C bond/cleavage, the most important type of reaction in organic chemistry. Some of the artificial enzymes were applied to in-cell reactions as well as <em>in vitro</em> systems. The effects of the structural fluctuation in biomacromolecules on their functions have also been realized. This review article includes recent research examples of artificial metalloenzymes used to C<img style=](https://sdfestaticassets-eu-west-1.sciencedirectassets.com/shared-assets/16/entities/sbnd) | |
Keywords: | Corresponding author. Artificial metalloenzyme Diels-Alder reaction Olefin metathesis Cyclopropanation |
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