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Et2Zn-mediated stoichiometric C(sp)-H silylation of 1-alkynes and chlorosilanes |
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| Authors: | Pan Huang Dawen Xu Robert M. Reich Felix Kaiser Boping Liu Fritz E. Kühn |
| Affiliation: | 1. State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China;2. Molecular Catalysis, Catalysis Research Center and Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, 85747 Garching bei München, Germany |
| Abstract: | A first example of an Et2Zn mediated silylation of 1-aklynes is reported. A series of functional groups are tolerated in this reaction. Mechanistic studies support Zn alkynilides as intermediates in the reaction. This reaction protocol provides a practical method for the preparation of alkynylsilanes and expands the application of organometallic zinc in organic synthesis. |
| Keywords: | Corresponding author. C(sp)-H silylation 1-Alkynes Alkynylsilanes |
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