CuI/Cu(OTf)2/DMSO system-catalyzed intramolecular oxidative cyclization of (o-alkynyl)arylketones: Efficient synthesis of 1,4-naphthoquinones |
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| Authors: | Bingwei Zhou Qian Liu Heng Wang Hongwei Jin Yunkui Liu |
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| Affiliation: | State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, China |
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| Abstract: | A concise and efficient method for the synthesis of 1,4-naphthoquinones has been successfully developed involving a CuI/Cu(OTf)2/DMSO system-catalyzed intramolecular oxidative cyclization of (o-alkynyl)arylketones. The present protocol provided a novel approach to access functionalized 1,4-naphthoquinones from non-naphthoquinone precursors with good selectivity and functional group tolerance. |
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| Keywords: | Corresponding author. 1,4-Naphthoquinones Copper catalysis Annulation Selectivity Tandem reaction |
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