Naturally occurring antitubercular cyclic peptides |
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Authors: | Shengping Zhang Iman Kavianinia Margaret A. Brimble |
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Affiliation: | 1. School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland 1142, New Zealand;2. Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1142, New Zealand |
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Abstract: | The antibiotic pipeline has failed to keep pace with the rise of multidrug resistant tuberculosis and extensively drug-resistant tuberculosis pathogens. Naturally occurring peptides provide a rich source of lead compounds for developing novel pharmaceuticals with high selectivity and potency. Given the vast number of naturally-occurring bioactive cyclic peptides identified so far, the following digest highlights several cyclic peptides, discovered in the preceding decade, that exhibit promising activity against Mycobacterium tuberculosis. |
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Keywords: | Corresponding author at: School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland 1142, New Zealand. Tuberculosis Cyclic peptides Peptide synthesis |
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