Kyanamide,a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata |
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| Authors: | Kaori Ozaki Arihiro Iwasaki Kiyotake Suenaga Toshiaki Teruya |
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| Institution: | 1. Graduate School of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan;2. Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohuku-ku, Yokohama, Kanagawa 223-8522, Japan |
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| Abstract: | Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC50 values of 0.13 nM and 1.1 μM. |
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| Keywords: | Corresponding author Marine natural products Caldora penicillata Cyclic depsipeptide Serine protease inhibition |
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