Cytotoxic aromatic polyketides from an insect derived Streptomyces sp. NA4286 |
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| Authors: | Ping Cheng Kuang Xu Yan Chi Chen Ting Ting Wang Yu Chen Cheng Long Yang Shi Ying Ma Yong Liang Hui Ming Ge Rui Hua Jiao |
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| Affiliation: | 1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China;2. State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China |
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| Abstract: | ![]()
Chemical study of the insect-derived bacterium, Streptomyces sp. NA4286, led to the discovery of four new polyketides, murayaquinones B-E (1–4), together with a known compound, murayaquinone (5). The structures of new compounds (1–4) were determined by extensive analysis of their NMR and HRESIMS data. The absolute configuration of (+)-1 and (?)-1 was assigned through comparison of experimental and calculated ECD spectra. Murayaquinone D (3) exhibited potent cytotoxic activities against six human cancer cell lines with IC50 values ranging from 1.03 to 9.99 μM. |
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| Keywords: | Corresponding authors. Murayaquinone Structure elucidation Cytotoxic activity |
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