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First enantioselective synthesis of salinipostin A,a marine cyclic enol-phosphotriester isolated from Salinispora sp |
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| Authors: | Hironori Okamura Takanobu Fujioka Naoki Mori Tohru Taniguchi Kenji Monde Hidenori Watanabe Hirosato Takikawa |
| Affiliation: | 1. Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;2. Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-ku, Sapporo 001-0021, Japan |
| Abstract: | Salinipostins are cyclic enol-phosphotriesters isolated from a marine-derived Salinispora sp. as antimalarial compounds. Herein, the first enantioselective synthesis of salinipostin A was achieved. Organocatalyst-mediated asymmetric cyclopropanation and regioselective cyclopropane ring opening were the key steps. |
| Keywords: | Corresponding author. Salinipostins Marine natural product Asymmetric cyclopropanation Hayashi-Jørgensen catalyst |
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