Catalyst- and organic solvent-free synthesis of thioacids in water |
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| Authors: | Mohamed Elagawany Lamees Hegazy Bahaa Elgendy |
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| Affiliation: | 1. Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO 63110, USA;2. Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, MO 63110, USA;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt;4. Chemistry Department, Faculty of Science, Benha University, Benha 13518, Egypt |
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| Abstract: | ![]()
Thioacids and thioamino acids were synthesized in excellent yields from readily available acyl benzotriazoles and sodium hydrosulfide in water at room temperature. The new methodology features mild reaction conditions, high yields, short reaction times, and does not involve the use of organic solvents or bases. The reaction is eco-friendly, and the workup procedure is simple and does not require chromatographic separation. |
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| Keywords: | Corresponding author at: Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, MO 63110, USA. Thioacids Water Green chemistry Catalyst free |
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