I2-promoted tandem cyclization to synthesize polysubstituted pyrano[3,2-c]chromene-2,5-diones |
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| Authors: | Qun Cai Shiyi Zhuang Mian Yang Na Peng Yi Liu Anxin Wu |
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| Affiliation: | 1. Coal Conversion and New Carbon Materials Key Laboratory of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, PR China;2. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China;3. State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine(MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China |
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| Abstract: | ![]()
An efficient and convenient method for the synthesis of various substituted pyrano[3,2-c]chromene-2,5-diones was developed via the I2-promoted tandem cyclization of commercially available aryl methyl ketones and 4-hydroxycoumarins. Preliminary mechanism studies indicated that the reaction involved a consecutive iodination/Kornblum oxidation/annulation process. HI produced in the I2-DMSO system acted as an important promoter, accelerating the annulation protocol. |
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| Keywords: | Corresponding author. Tandem cyclization Aryl methyl ketones 4-Hydroxycoumarins |
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