A consecutive one-pot two-step approach to novel trifluoromethyl-substituted bis(indolyl)methane derivatives promoted by Sc(OTf)3 and p-TSA |
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| Authors: | Xinxin Yuan Lulu Wu Cuilian Xu Zhenliang Pan Lijun Shi Guoyu Yang Caixia Wang Sufang Fan |
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| Affiliation: | 1. College of Resource and Environment, Henan Agricultural University, Zhengzhou 450002, PR China;2. School of Science, Henan Agricultural University, Zhengzhou 450002, PR China |
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| Abstract: | ![]()
A one-pot two-step reaction of 3-(trifluoroacetyl)coumarin and indole afforded trifluoromethyl-substituted bis(indolyl)methane compounds containing coumarin skeleton. The atomic economic and simply manipulative reaction involved premier treatment of reaction mixtures with Sc(OTf)3, followed by p-TSA in one-pot process. The reaction proceeded to give the title compounds in high yields (up to 95% yield). |
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| Keywords: | Corresponding authors at: School of Science, Henan Agricultural University, Zhengzhou 450002, PR China. Trifluoromethyl-substituted bis(indolyl)methane Coumarin derivatives Synthesis One-pot |
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