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A novel variant of the medicinally relevant 1,2,5-benzothiadiazepin-4-one-1,1-dioxide scaffold accessed via the downstream modification of Castagnoli-Cushman lactams |
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| Authors: | Liliia Usmanova Dmitry Dar&#x;in Mikhail Krasavin |
| Institution: | Saint Petersburg State University, Saint Petersburg 199034, Russian Federation |
| Abstract: | Downstream modification of piperazin-2-ones obtained by the Castagnoli-Cushman reaction leads to a novel version of the medicinally relevant 1,2,5-benzothiadiazepin-4-one-1,1-dioxide scaffold. The relative stereochemistry remained trans as evidenced by the spectroscopic data and the single-crystal X-ray analysis. |
| Keywords: | Corresponding author at: Laboratory of Chemical Pharmacology Institute of Chemistry Saint Petersburg State University 26 Universitetskii prospect Peterhof 198504 Russian Federation Castagnoli-Cushman reaction Nitro group reduction Lactamization Sultam |
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