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Photoredox mediated CN cross coupling of sulfoximines with aryl iodides
Authors:Sudhir Hande  Adelphe Mfuh  Scott Throner  Ye Wu  Qing Ye  XiaoLan Zheng
Institution:Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Boston, United States
Abstract:A new photoredox-catalyzed C />N coupling reaction of sulfoximines with aryl halides has been developed for a general <em>N</em>-arylation of sulfoximines. The reactions proceed in the presence of visible light with high levels of chemoselectivity and a wide range of functionality is tolerated. There is a rapidly increasing interest in sulfoximines as pharmacophores in drug discovery and this new method offers potential in terms of high functional group tolerance and late-stage functionalization of compounds.</td>
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Keywords:Corresponding author    Sulfoximine  Photo redox  Ni-catalyst
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