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Highly effective and enantioselective Phospho-Aldol reaction of diphenyl phosphite with N-alkylated isatins catalyzed by quinine |
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| Authors: | Lin Peng Liang-Liang Wang Jian-Fei Bai Li-Na Jia Qing-Chuan Yang Qing-Chun HuangXiao-Ying Xu Li-Xin Wang |
| Institution: | a Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China b Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China |
| Abstract: | Cinchona alkaloids were first successfully reported to promote enantioselective Phospho-Aldol reaction of diphenyl phosphite to a variety of N-alkylated isatin derivatives in good to excellent yields (up to 99%) and moderate to good enantioselectivities (up to 73% ee) almost in no time. |
| Keywords: | Quinine Organocatalyst Phospho-Aldol reaction Diphenyl phosphite N-alkylated isatins |
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