Diastereoselective synthesis of the indeno-tetrahydropyridine core bearing a diaryl-substituted stereogenic quaternary carbon center of haouamine B |
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| Authors: | Tanaka Takeshi Inui Hiromi Kida Hiroshi Kodama Takeshi Okamoto Takuya Takeshima Aki Tachi Yoshimitsu Morimoto Yoshiki |
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| Institution: | Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585, Japan. |
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| Abstract: | The characteristic indeno-tetrahydropyridine core of cytotoxic haouamine B (2) was efficiently synthesized featuring the diastereoselective construction of a diaryl-substituted stereogenic quaternary center by an intramolecular Pd-catalyzed α-C-arylation and subsequent direct conversion of the vinylogous imide function into the C2-C25 double bond by TsNHNH(2). |
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