Design of polylactide-grafted copolymeric stabilizer for dispersion polymerization of D,L-lactide |
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Authors: | Makoto Muranaka Hidekazu Yoshizawa Tsutomu Ono |
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Institution: | (1) Department of Material and Energy Science, Graduate School of Environmental Science, Okayama University, 3-1-1 Tsushima-Naka, Okayama 700-8530, Japan |
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Abstract: | Poly(D,L-lactide) (PDLLA) microspheres with narrow diameter distribution were prepared by dispersion polymerization of D,L-lactide
in xylene/heptane (1:2, v/v) using poly(dodecyl methacrylate)-g-poly(D,L-lactide) (PDMA-g-PDLLA) as a dispersion stabilizer. The particle diameters of PDLLA microspheres were controlled from 200 nm to 5 μm by altering
the concentration and the graft chain number of PDMA-g-PDLLA. The effect of the copolymer composition on the particle diameter was investigated to clarify an important factor of
the copolymer structure for the control of the particle diameter. As a result, it was necessary for anchor block in diblock
copolymer as a dispersion stabilizer to have low solubility in the solution rather than the compatibility with particles.
Moreover, we confirmed by dynamic light scattering measurement that PDMA-g-PDLLA formed micelles in the solution. In conclusion, it was clarified that PDLLA microspheres with a wide range of particle
diameter were prepared due to the different kinetic stability of micelles. |
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Keywords: | Poly(D L-lactide) Microsphere Dispersion polymerization Graft copolymeric stabilizer Copolymeric micelles |
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