Synthesis of Novel <Emphasis Type="Italic">D</Emphasis>-<Emphasis Type="Italic">Seco</Emphasis>-Pregnenes |
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Authors: | János?W?lfling Angéla?Magyar Email author" target="_blank">Gyula?SchneiderEmail author |
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Institution: | (1) Department of Organic Chemistry, University of Szeged, H-6720 Szeged, Hungary, HU |
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Abstract: | Summary. A new synthetic route was developed for the preparation of trans-3-hydroxy-16,17-seco-pregna-5,17(20)-dien-16-al, using Grob fragmentation as the key step. This seco-steroid contains a formyl group and an unsaturated side-chain in a sterically favourable position, and is therefore a promising starting material for the synthesis of novel condensed steroid heterocycles.Received March 22, 2003; accepted April 22, 2003
Published online September 25, 2003 |
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Keywords: | , Steroids, Epoxidations, Reductions, Grob fragmentation, D-seco-pregnenes, |
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