Following aptamer-ricin specific binding by single molecule recognition and force spectroscopy measurements |
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| Authors: | Wang Bin Guo Cunlan Chen Guojun Park Bosoon Xu Bingqian |
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| Affiliation: | Single Molecule Study Laboratory, Faculty of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA 30602, USA. |
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| Abstract: | ![]()
Single molecule recognition imaging and dynamic force spectroscopy (DFS) analysis showed strong binding affinity between an aptamer and ricin, which was comparable with antibody-ricin interaction. Molecular simulation showed a ricin binding conformation with aptamers and gave different ricin conformations immobilizing on substrates that were consistent with AFM images. |
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