Synthesis of azanucleosides through regioselective ring-opening of epoxides catalyzed by sulphated zirconia under microwave and solvent-free conditions |
| |
Authors: | Hernández-Reyes Celia Xochitl Angeles-Beltrán Deyanira Lomas-Romero Leticia González-Zamora Eduardo Gaviño Rubén Cárdenas Jorge Morales-Serna José Antonio Negrón-Silva Guillermo E |
| |
Institution: | Departamento de Ciencias Básicas, Universidad Autónoma Metropolitana, Av. San Pablo No. 180, México D.F., C.P. 02200, Mexico. |
| |
Abstract: | New azanucleosides were obtained using sulphated zirconia (ZS) as catalyst in the nucleophilic oxirane ring opening reaction of 1-allyl-3-(oxiran-2-ylmethyl) pyrimidine-2,4(1H,3H)-dione and 1-allyl-5-methyl-3-(oxiran-2-ylmethyl)-pyrimidine-2,4(1H,3H)-dione, with (S)-prolinol. The new templates were obtained with good yields following a route which exploits the reactivity of epoxides in the presence of sulphated zirconia as catalyst. The key step was carried out using microwave and solvent-free conditions and proceeds with high selectivity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|