| 1-甲基-3,4-二苯基喹啉-2(1H)-酮的合成和结构表征 |
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| 引用本文： | 胡小灵,黄笑,唐建生.1-甲基-3,4-二苯基喹啉-2(1H)-酮的合成和结构表征[J].化学研究,2012(6):36-38. |
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| 作者姓名： | 胡小灵 黄笑 唐建生 |
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| 作者单位： | 湖南第一师范学院教科系 |
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| 基金项目： | 湖南省大学生研究性学习和创新性实验计划项目(422);湖南省科技厅项目(2011FJ3125) |
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| 摘 要： | 以N-甲基苯胺和苯丙炔酸为原料,经过缩合、亲电环化、偶联反应合成了1-甲基-3,4-二苯基喹啉-2(1H)-酮;利用核磁共振谱和气相色谱-质谱表征了产物的结构.结果表明,所用合成方法具有产率高、反应条件温和、操作简单等优点,目标产物的总产率达62.7%.
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| 关 键 词： | 1-甲基-3 4-二苯基喹啉-2(1H)-酮 合成 结构表征 |
Synthesis and structure characterization of 1-methyl-3,4diphenylquinolin-2(1H)-ketone |
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| HU Xiao-ling,HUANG Xiao,TANG Jian-Sheng.Synthesis and structure characterization of 1-methyl-3,4diphenylquinolin-2(1H)-ketone[J].Chemical Research,2012(6):36-38. |
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| Authors: | HU Xiao-ling HUANG Xiao TANG Jian-Sheng |
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| Institution: | (Department of Educational Science,Hunan First Normal University,Changsha 410205,Hunan,China) |
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| Abstract: | 1-Methyl-3,4-diphenylquinolin-2（1H）-ketone was synthesized through the etherification,iodocyclization,and Suzuki-Miyaura cross-coupling reaction of N-methylaniline and 3-phenylpropiolic acid as the starting materials.The structure of as-synthesized product was characterized by means of nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry.Results indicate that the established synthetic method is advantageous with high yield,mild reaction condition,and simple operation;and the target product can be obtained in a total yield of 62.7%. |
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| Keywords: | 1-methyl-3 4-diphenylquinolin-2（1H）-ketone synthesis structure characterization |
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