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Fractional scanned carbon dioxide laser induces collagen remodelling in murine dermis |
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| Authors: | X Jiang H M Ge J J Liu Q S Ren |
| Institution: | 1. Institute for Laser Medicine and Bio-Photonics, Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China 2. Institute of Dermatology and Department of Dermatology at NO. 1 Hospital, Anhui Medical University, Hefei, Anhui, 230032, China 3. Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China |
| Abstract: | Resurfacing using a fractional CO2 laser shows an important promise in the therapy on photoaged skin. The present study investigated that fractional CO2 laser with a special sequential scanned manner induced the collagen remodelling in murine dermis. The results showed that laser resulted in the improvement of elasticity and histology in the murine dermis, meaning laser efficacy depends on both of the collagen formation and organization. We further investigated the relations between skin elasticity and type I, and type III collagen. These data demonstrated that laser could significantly lead to the collagen remodelling in murine dermis and induce neocollagenisis as a mode of resurfacing. |
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