Converting the sacrificial DNA repair protein N-ada into a catalytic methyl phosphotriester repair enzyme |
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| Authors: | He Chuan Wei Hua Verdine Gregory L |
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| Affiliation: | Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, Massachusetts 02138, USA. |
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| Abstract: | ![]()
Mutation of the active-site residue Cys38 of N-Ada converts it from a sacrificial DNA repair protein to an enzyme that uses methanethiol as an external sacrificial reagent to repair DNA methyl phosphotriesters catalytically. |
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