联萘酚与固体支撑双层类脂膜相互作用

采用循环伏安法、交流阻抗法研究了联萘酚(BINOL)与固体支撑双层类脂膜(s-BLM)之间的相互作用.结果表明,联萘酚通过氢键、疏水作用与s-BLM发生相互作用.随着相互作用时间的延长,联萘酚/s-BLM体系中的氧化峰电流先增大后减小,表明联萘酚逐渐破坏s-BLM的整体性,诱导膜内部形成微孔通道.联萘酚的浓度越大,联萘酚分子通过s-BLM的渗透时间越短.此外,随着卵磷脂浓度和胆固醇含量的增加,s-BLM的膜电阻变大,联萘酚渗透通过s-BLM速率减小,导致其对s-BLM的渗透性能减弱.

Interaction between[1,1'-Binaphthalene]-2,2'-diols and a Solid Supported Bilayer Lipid Membrane

The interaction between [1,1'-binaphthalene]-2,2'-diols (BINOL) and a solid supported bilayer lipid membrane (s-BLM) was studied by cyclic voltammetry and alternating current (AC) impedance measurements. Results indicate that BINOL interacts with s-BLMthrough hydrogen bonding and hydrophobic interaction. The oxidation peak current of the BINOL/s-BLMsystem increases initially and then decreases with an increase in time. This suggests that BINOL gradually destroys the integrity of s-BLM and induces the formation of microchannels within the membrane. The infiltration time of BINOL through the s-BLM decreases as the BINOL concentration increases. With an increase in lecithin and cholesterol content, the membrane resistance of s-BLM increases and the infiltration rate of BINOL through the membrane decreases, which results in a reduction of the infiltration capacity of BINOL towards s-BLM.