Über die Synthese von 1,3-Dihydro-3-(2-dimethylaminoäthyl)-1-(3-thienyl)-benzimidazol-2-onen |
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| Authors: | Prof Dr Otto Hromatka Dieter Binder Karl Eichinger |
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| Institution: | 1. Institut für Organische Chemie der Technischen Hochschule Wien, Getreidemarkt 9, A-1060, Wien, ?sterreich
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| Abstract: | The synthesis of 1-(3-thienyl)-benzimidazol-2-ones (3 a and4), described in an earlier paper1, has been further investigated. The Na-salt of3 a is converted to a benzimidazolone substituted in position 3 (3 b). Dehydrogenation of the thiophene nucleus of3 a with chloranil yields5 a, which undergoes substitution in position 3 with Cl(CH2)2N(CH3)2 to give5 b. Monochlorination of5 a yields5 c, the structure of which is confirmed by1H-NMR-spectroscopy.5 d is obtained by reaction of the Na-salt of5 c with Cl(CH2)2N(CH3)2. |
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